TU meat & move
Period: 11.2015 – 31.12.2016
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Dr. habil. Stefan Breuer
FB 5, Semiconductor Optics Group
PD Dr. Tobias Meckel | M.Sc. Robert Lehn
FB 10, SFB 1194
Prof. Dr. Helmut Schlaak | Dipl.- Ing. Tanja Grotepaß | Dipl.-Ing. Thomas Winterstein
FB 18, Elektrotechnik und Informationstechnik
Dr. Ljubomira A. Schmitt
FB 11, Material- und Geowissenschaften
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Project Description:
The scientific goal of this interdisciplinary project is the development of a paper based platform for the three-dimensional cultivation, movement, contactless detection and microscopic analysis of cells. By imposing detailed gradients and stimulating physical activity of the micro cultures of mammalian cells, internal cell transport mechanisms can be induced. Basis of the project are newly developed paper- hydrogel-composites with optimized material properties and specific characteristics that allow to deform by purpose the embedded hydrogels. Integration of different new technical approaches of new micro-actors into the paper substrate facilitated micro-actuation and movements of the paper substrate. The position control and compensation of possible axial movement of the cell-containing hydrogels shall be performed by new contactless semiconductor photonics based laser interferometry. This should enable a re-positioning of the microscope objective. Finally, by new approaches to high-resolution microscopy, the moving cells will be tracked and analysed.
Thesis:
D. Hartnagel, Bachelor-Thesis, Institut für Angewandte Physik, zum Thema Halbleiteraserbasierte Abstands-Sensorik, 17. Oktober 2016, Zweitgutachter T. Meckel
C. Weber, Doktor-Thesis, Institut für Angewandte Physik, mit Teilthema zur Zweiphotonen-Mikroskopie mittels nanostrukturierter Halbleiterlaser, Abschluss 2021 (in Vorbereitung)
Conference Contribution:
D. Hartnagel et al., ”Absolute distance semiconductor laser self- interferometry towards microscopy object position detection,“ Poster Präsentation, DPG Frühjahrstagung, HL 64.39, Dresden, 22 März 2017
FiF-Event:
„TU meat & move“ – Zellkulturen in Bewegung In: 2. Tag der Interdisziplinarität, Forum für interdisziplinäre Forschung, Darmstadt, 5. November 2018
Journal Article:
C. Weber et al., „Zweiphotonen-Mikroskopie mittels nanostrukturierter Halbleiterlaser“, Experimentelle Demonstration verbesserter Zweiphotonen-Mikroskopie, Institut für Angewandte Physik, in Vorbereitung zur Einreichung bei einem Fachjournal in 2021p
