Period: 11.2017 – 4.2019
Prof. Dr. Beatrix Süß | Dr. Florian Groher | Jeannine Schneider, M. Sc.
FB 10, Synthetische Genetische Schaltkreise
Prof. Dr. Edgar Dörsam | Dr.-Ing Dieter Spiehl | Jacqueline Balles, M. Sc.
FB 16, Institut für Druckmaschinen und Druckverfahren
In this project, printed biosensors for the detection of antibiotic residues in food were developed in cooperation between biology and mechanical engineering. The underlying idea is that antibiotics such as ciprofloxacin (CFX) and tetracycline (Tc), which are present as residues in food, have intrinsic fluorescence which is reduced (quenched) by binding to a suitable RNA aptamer. The Biology Department has developed a detector system that synthesizes and analyzes aptamers and makes them available for compression tests. The Mechanical Engineering department established the printing process, i.e. a suitable printing process, ink formulation, substrate and design. Preliminary work led to first publications at a conference  and in a journal , both for printing technology. Based on the results, a CFX aptamer was established and a biosensor was printed by inkjet printing, which was also published . In further cooperation, a universal detector system will be developed, which can be visually read by a color change of gold nanoparticles. A DFG proposal is currently being finalised.