Duration: 7.2024 – 6.2025

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Project team:

Prof. Dr.-Ing. Eckhard Kirchner
FB 16, Product Development and Machine Elements

Prof. Dr. Ulrike A. Nuber
FB 10, Stem cell and developmental biology

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Project description:

The aim of the project is to develop methods for electrical impedance measurements of three-dimensional (3D) human tissue models produced in the laboratory. Two different approaches will be developed: direct contact measurements (a) with microelectrodes and contactless in-situ measurements via inductive coupling (b) using the same measuring approach to characterize the tissue model. This project is motivated by the need to non-destructively and continuously monitor conditions of 3D tissue models. It addresses a technological gap and insufficient understanding of the cellular parameters that influence impedance measurements in 3D tissue models of larger size. Concepts and methods from mechanics will be transferred to biology to establish new measurement approaches and derive new ways to characterize different states of 3D tissue models.