Period: 7.23-12.25

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Prof. Dr. rer. nat. habil. Torsten Frosch
FB 18, Fachgebiet Biophotonik – Medizintechnik

Prof. Dr. Andreas Blaeser | FB 16, Fachgebiet BioMedizinische Drucktechnologie

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Project description:

We aim to explore novel optical spectroscopic techniques to improve patient care at the point-of-care, and to this

end, we are bringing together our interdisciplinary expertise. The quantification of drugs in bodily fluids is of

great importance for personalized medicine. For the successful treatment of critically ill patients and when treating

patients with drugs that have a narrow therapeutic window, therapy should be individually tailored to the patient’s

current physical condition. For this reason, therapeutic drug monitoring – that is, monitoring current drug levels

in the blood – is highly important for preventing underdosing, which carries the risk of treatment failure, and

overdosing, which carries the risk of drug accumulation and toxic side effects. To develop a measurement

technique for this purpose, we are pooling our technological expertise. The unique advantages of amplified Raman

spectroscopy – namely, short analysis time, small sample volume, and high sensitivity, combined with the ability

to detect multiple components – are expected to pave the way for a future point-of-care approach to the sensitive detection of active substances in bodily fluids.